Recent Advances in Hepatotoxicity of Non Steroidal Anti-inflammatory Drugs

Systematic review: the hepatotoxicity of non-steroidal anti-inflammatory drugs.

BACKGROUND Non-steroidal anti-inflammatory drugs have been implicated in reports of liver injury. However, the precise risk of non-steroidal anti-inflammatory drugs for this rare complication is unknown. AIM To review systematically the published literature of population-based epidemiological studies reporting the incidence or comparative risk of non-steroidal anti-inflammatory drugs for live...

Cross hepatotoxicity between non-steroidal anti-inflammatory drugs.

I Lyell A. The staphylococcal scalded skin syndrome in historical perspective: emergence of dermopathic strains of Staphylococcus aureus and discovery of the epidermolytic toxin. A review of events up to 1970. 7 Am AcadDermatol 1983;9;:285-94. 2 Melish ME, Glasgow LA. The staphylococcal scalded skin syndrome. Development of an experimental model. NEnglJMed 1970;282:1114-9. 3 Dowsett EG, Petts D...

Non-steroidal anti-inflammatory drugs.

Safety of non-steroidal anti-inflammatory drugs.

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used in medical practice for treating pain, inflammation and degenerative joint diseases (for instance, arthritis). The use of traditional NSAIDs (tNSAIDs), however, is associated with an increased risk of minor and serious gastrointestinal (GI) events. It is estimated that in the European Union thousands of gastrointestinal complication...

Isobolographic antinociception of non-steroidal anti-inflammatory drugs in rodent formalin orofacial pain

Diverse studies suggest that non-steroidal anti-inflammatory drugs (NSAIDs) induce antinociception through inhibition of cyclooxygenases. In this study was evaluated the effect of NSAIDs to induce antinociception either alone or in combination in the formalin orofacial test of rodent. Male mice were injected intraperitoneally with dexibuprofen, dexktoprofen, diclofenac meloxicam, metamizol, and...